Hi Aimee. Thanks for the reply. I really appreciate your comment on Rescue Remedy. I have felt that it helps him after a seizure so I do hate to discontinue it now – especially after the cluster.
This shaking (without a full seizure) is definitely much more intense than a tremor. And completely out of his control. But it has become a little less intense since the first couple times it happened. The first couple times he would also pant for a minute or two after it stopped, but now he just takes a deep breath when it stops and then starts napping, but with subtle signs of discomfort.
When he has a full seizure, the progression every time is this: (1) he starts looking around like he hears something, for 3-5 seconds; (2) shakes violently for 3-5 seconds; (3) tonic phase of seizure where he goes rigid for 15 seconds or so; (4) clonic phase with paddling of all limbs and much foaming at the mouth, for about 1 minute. Afterwards he remains lying down, eyes wide open and looking scared to death, and pants REALLY heavily for 5 minutes or so.
The first couple shaking episodes (without a full seizure) I think it started with looking around first, but I’m not sure. Now, I don’t see him doing that, or if he is it is more subtle.
The lack of the appetite in the morning has come and gone in the last year, but has been pervasive for the last few weeks. Until a couple months before the seizures started he always had a good appetite. His appetite first started to wane when he was on Rimadyl for a few weeks, and the lack of appetite was most noticeable in the morning. Since then, there have been so many changes (food, supplements) that could have upset his stomach that it is hard to sort it all out. One thing that has been pretty consistent since the seizures started is that he is consuming more fat than he was previously, so I really have to wonder if he has developed digestion problems centered around that. I have cut back significantly on the fatty foods in the last few days, and stopped the MCT Oil. Yesterday he had no breakfast, and today a small one but less fatty than before. No shaking yesterday or today. But, two data points is far from conclusive. 🙁
On your CBD Oil pharmacokinetics question – I have not read much on that, but I do have a 2019 study (published in Animal) in my voluminous collection of seizure reading. They found “…time to maximal concentration (Tmax) of 1.4 h and 2 h, for dogs and cats, respectively” and “… half- elimination rates of approximately 4 h in dogs”
Back when I was giving him a full dose of CBD Oil, he got it in the morning typically about an hour before eating and in the evening right before eating. I had stopped the CBD completely on 1/20. He then had the first cluster of 3 seizures on 2/6 and the first shaking episode on 2/9. I restarted the CBD on 2/10, in the morning only, at a lower dose. None yesterday and today.
I’m not sure that I mentioned this before, but he has been on SAMe (800 mg/day) since the first high enzyme bloodwork. He gets that in the middle of the day.
I could go on and on, but will control myself. I imagine you do have other things to do. Thanks for taking the time to consider and comment. M&C
