Hi Jane,
I do see your logic regarding the effects on the liver…I am posting an portion of a research study…please note the extremely high dosages given to the rats…400mg per Kg body weight a DAY…a DAY. Wow…my gal got about 11.4 mg per pound for 3 months ( (roughly 23.6 mg per kg per 90 days!!!)
Jane…anything to excess is dangerous. Drinking to much water at once can literally kill you…does than mean water is toxic. Well yes…sure it is toxic if you are stupid enough to drink 3 or 5 gallons at once.
How about baby aspirin..yep..thats toxic to in some people. If I listed all the side effects of just plain old aspirin and didn’t tell you the drug name there is no way you would ever pop another aspirin again. Yet rarely do any of us ever actually realize any negative effect from aspirin and there are many studies that support aspirin has numerous beneficial effects at low dosage…from preventing heart disease to preventing some cancers.
Some people don’t seem to have comon sense…they read a “study” and don’t really have the expertise to understand the study then they get freaked out.
Please…do go read all the horrible…super scary possible side effects of aspirin…but you know what…I’m not concerend at all and I think it makes perfect sense to take a daily low dose of aspirin…the logical benefits are far better than the risks.
But yes…see my other posts…keep an eye on this…know your dog…get proper blood tests done and see how your pup is tolerating this new drug.
Please see below post from PARASITIPEDIA.net:
LD50 acute, rats, p.o. >2000 mg/kg
LD50 acute, rats, dermal >2000 mg/kg.
In rats the main target organ in the repeated dose toxicity studies was the liver. Increased organ weight, hepatocellular fatty change and effects in related blood parameters were observed mainly in the highest dose groups, thus at large overdoses relative to recommended/proposed use in the dogs. At the dose of 400 mg/kg bw/day effects on thymus and adrenal weight and microscopic changes in lung and thymus were observed. Comparable effects were reported after dermal administration at very high doses.
In Beagle puppies treated at 1x, 3x and 5x the maximum recommended dose (= 25 to ~60 mg/kg bw) three times with a 56 day interval, fluralaner was well tolerated. There was no evidence of product-related effects in food consumption, body weight, clinical parameters or physical examination variables, or clinical pathology findings.
In a pivotal reproductive study Beagle dogs were treated up to 3X the recommended dose 3 times at 8 weeks intervals starting 12 weeks (males) and 4 weeks (females) before expected mating. Treatment continued until the females had whelped (males) or the puppies were weaned (females). No adverse reactions were observed in adult dogs and no detrimental effect on reproductive functions, number of puppies and puppy survival was detected.
Safety data collected during field studies with the tablets for dogs in Europe and the USA showed that the product was in general well tolerated. In the European field study mild and transient diarrhea, vomiting, lack of appetite and drooling were recorded in 1.6% of dogs in the first days after treatment.
