Red,
Are you familiar with liver disease in dogs, including high ALT? Are you familiar with Denamarin? It is a PRESCRIPTION medication given by vets to support liver function. Do you know what the ingredients are in Denamarin? They are Sam-e and MILK THISTLE. I have actually reduced high ALT from well over 300 to the completely normal (actually on the low side of normal) on a dog diagnosed with chronic hepatitis using a combination of Sam-e and MILK THISTLE (the vet verified that this could be used in place of the prescription). I use vets and Lab tests, so this is not guessing, Voodoo or witchcraft. I also know many people who have done the same that are knowledgable people in the dog world who also used vets to diagnose, etc. that have successfully used this therapy.
Here are some links to studies or research done:
http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.0743.x/full
http://www.fvmace.org/FVMA%2082nd%20Annual%20Conference/Proceedings/Update%20On%20Management%20of%20Liver%20Disease%20in%20Dogs.pdf
This is for humans, and it includes many diseases unrelated to the liver, but it does suggest that there is efficacy in milk thistle use:
http://www.mayoclinic.org/drugs-supplements/milk-thistle/evidence/hrb-20059806
You might want to consider reading other sources besides skeptvet.
