[Gene B]

Gracie, my 15 year old terrier mix had a bad reaction to Galliprant.
Had taken her in this week for a vaccine shot.
Vet suggested trying galliprant for arthritis.
Gracie’s been on temaril p for several years to help with chronic nasal discharge.
Temaril P is an antihistamine with a low dose of Prednisone.
Vet told me galliprant is OK to use with temaril p
Gave Gracie 1/2 temaril p and 1/2 of 20mg galliprant with her morning food.
If afternoon Gracie had other 1/2 of temaril p, no galliprant.
In the evening Gracie started panting, pacing, peeing for about 5 hours non stop.
Urine had blood in it.

Next day Gracie still had to pee more than normal and still had blood in the urine, and no more pacing around or panting. Didn’t give her any more galliprant, also skipped temaril p for the day.
Next evening Gracie still had to pee about every 5 minutes, but acting normal and less blood in the urine.

Found https://veterinarypartner.vin.com/default.aspx?pid=19239&id=7933279
“Interactions with other Drugs
Grapiprant use in combination with corticosteroids (prednisolone, dexamethasone, triamcinolone, etc.) has not been studied and the manufacturer recommends against concurrent use of these medications. Similarly, grapiprant should not be used with NSAIDs.

Grapiprant is highly protein-bound and this is a potential problem when it is used with other highly protein-bound medications.

Grapiprant is a highly protein-bound medication. What that means is that in the bloodstream, 95 percent of grapiprant is transported bound to an albumin (carrier protein) molecule while the rest is floating free in the bloodstream. The five percent that is floating free is the active portion. As the free portion is removed from the body by the liver, the blood protein gives up what it is carrying to replace it. This continues until all of the drug has been removed by the liver. Problems can result when other highly protein-bound drugs are used concurrently. The drugs will “fight” over places on the albumin carrier molecule (imagine a bus with only a certain number of seats and too many passengers trying to fill them). The drug with the higher protein affinity will be carried and the other drug is left floating free and active, meaning there will be much more active drug than normal. This can lead to toxicity problems. Grapiprant has not been tested with other drugs in this way so how significant an issue this is remains to be seen.”