I live in the northeast, where lyme disease is a very real threat. We use Frontline Plus on our 63 lb boxer/rottie mix and the rescue I volunteer for (and that we adopted our dog from) uses Frontline Plus on all of their dogs. I have not heard of anyone having issues. We also have our dog vaccinated for Lyme, as recommended by our vet.
I order my Frontline from Amazon because it is so much cheaper than I can get anywhere else, but I have been careful to check all of the packaging and product codes to make sure they are genuine because I have heard of fake products being delivered through online channels. So far, we have not had any issues, and our dog has remained flea and tick free.
