Just some info bits i’m picking up here and there;
Pharmacokinetics of Milbemycin Oxime
After oral administration to dogs milbemycin oxime is quickly and almost completely absorbed. Peak plasma concentration is reached 2 to 4 hours later, and subsequently declines with a half-life of 1-3 days. Bioavailability is about 80%.
In rats, metabolism seems to be complete, since unchanged milbemycin oxime was not found in urine or feces. High concentrations of milbemycin oxime are found in the liver and in body fat.
As a general rule, due to a different pharmacokinetic behavior the anthelmintic effect is longer for milbemycin oxime than for ivermectin, although this strongly depends on the delivery form and the administered dose.
http://parasitipedia.net/index.php?option=com_content&view=article&id=2673&Itemid=3005
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WARNING: Dogs of some breeds are sensitive to milbemycin oxime, other macrocyclic lactones or other drugs (e.g. emodepside) that can cross the blood-brain barrier. They can suffer more or less serious adverse effects if treated at dose rates higher than the recommended ones. Consequently dosing must be as accurate as possible. This is the case for Collies and related breeds, which have a mutation in the MDR-1 gene that affects the blood-brain barrier and makes it more permeable to such compounds than in dogs without this mutation. Besides Collies, other dog breeds have shown similar problems, although the MDR-1 mutation has not been confirmed in all of them. The breeds more affected by this mutation are (% frequency): Collie (70%), Long-haired Whippet (65%), Australian Shepherd (50%, also mini), McNab (30%), Silken Windhound (30%), English Shepherd (15%), Shetland Sheepdog (15%), English Shepherd (15%), German Shepherd (10%), Herding Breed Cross (10%). Other less affected breeds are: Old English Sheepdog, Border Collie, Berger Blanc Suisse, Bobtail, WƤller. The only way to be sure that a dog is affected or not by the MDR-1 gene defect is to test for it. As more dogs are tested it is likely that the mutation is discovered in other breeds, or that the frequencies change. Besides Collies, other dog breeds have shown similar problems, although the MDR-1 mutation has not been confirmed in all of them. The breeds more affected by this mutation are (% frequency): Collie (70%), Long-haired Whippet (65%), Australian Shepherd (50%, also mini), McNab (30%), Silken Windhound (30%), English Shepherd (15%), Shetland Sheepdog (15%), English Shepherd (15%), German Shepherd (10%), Herding Breed Cross (10%). Other less affected breeds are: Old English Sheepdog, Border Collie, Berger Blanc Suisse, Bobtail, WƤller. The only way to be sure that a dog is affected or not by the MDR-1 gene defect is to test for it. As more dogs are tested it is likely that the mutation is discovered in other breeds, or that the frequencies change.
http://parasitipedia.net/index.php?option=com_content&view=article&id=2673&Itemid=3005
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This is only referring to humans, and they don’t mention anthlemintics here, most people don’t use dewormers though.
“Inform the doctor if you are also on anxiolytics, antipsychotics, anticoagulants, anticancer drugs, statins, and seizure prevention drugs, as most of these are worked upon by some major hepatic enzymes and thus, milk thistle might disrupt their course of action.”
http://www.buzzle.com/articles/milk-thistle-dosage.html
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A bit on moxidectin
Pharmacokinetics of Moxidectin
After absorption into blood moxidectin is well distributed throughout the whole body including target organs such as the gastric and gut mucosae. The highest concentrations are found in body fat that acts as a depot from where it is progressively released to blood. Moxidectin is more lipophilic than ivermectin and consequently it is stronger deposited in body fat, which results in a higher residual effect and a longer protection against several parasites than ivermectin (by comparable delivery form and administered dose).
http://parasitipedia.net/index.php?option=com_content&view=article&id=2669&Itemid=3008
