Hey All, my dog (2 yr old 40-45lb Plott Hound) probably has Chylothorax. It looks exactly like it but we’re waiting on test results to rule out lymphoma and infection.
Researching this online I’ve found (like you all) that I should add Rutin to her new low-fat diet. So I ordered some. I’m trying to understand the dosing though. From what I can tell Rutin’s possible mechanisms for helping are poorly understood at best, but also that it has a very low or unknown toxicity. I’ve run across people citing 50 – 100 mg/kg body weight as a recommended dose, but I’ve found no reason for those numbers. Is it pure guess work?
I’ve found the LD95 of Rutin for rats of 19.5 g/kg, which is enormous. Various sources claim no effects for male rats at all until somewhere between 500 – 2500 mg/kg, and females can take even more. I haven’t found this data for dogs.
So, I’m betting dogs can take a lot more than 100 mg/kg, and I don’t know why that’s the number that’s floating around everywhere. My guess is some researcher picked it out of the air and ran with it. It seemed safe, so it stuck. For sure though, there seems to be a big lack of info on Rutin as a treatment :/
I think I’m going to give my dog more, but I’m trying to decide how much. For now I’ll start off at ~ 200mg/kg. Perhaps she’ll just pee it out like taking a lot of Vitamin C, but it seems very unlikely to hurt.
