http://yourpetsneedthis.com/zoetis-simparica-bravecto-nexgard/
This has interesting information. Including this.
FURTHER INVESTIGATION NEEDED!!
I am astounded to read the final paragraph under Animal Safety on the product insert. I’ve included it word-for-word below. For me, these are simply the most intriguing four sentences I have read ALL YEAR.
Why?
Because I believe whatever happened in this dog is the VERY process that is occurring in all of the dogs who’ve experienced side effects with Bravecto and Nexgard. Some of these dogs have died. We must determine what is happening here!
“In a separate exploratory pharmacokinetic study, one female dog dosed at 12 mg/kg (3X the maximum recommended dose) exhibited lethargy, anorexia, and multiple neurological signs including ataxia, tremors, disorientation, hypersalivation, diminished proprioception, and absent menace, approximately 2 days after a third monthly dose. The dog was not treated, and was ultimately euthanized. The first two doses resulted in plasma concentrations that were consistent with those of the other dogs in the treatment group. Starting at 7 hours after the third dose, there was a rapid 2.5 fold increase in plasma concentrations within 41 hours, resulting in a Cmax more than 7-fold higher than the mean Cmax at the maximum recommended use dose. No cause for the sudden increase in sarolaner plasma concentrations was identified.“
3 months, 1 week ago
