US Adopted Name “fluralaner” is: 4-[5-(3,5-Dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-m- ethyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide (CAS RN [864731-61-3]).
The liver produces and secretes bile into the intestine where the bile assists with the absorption and digestion of dietary fat. The liver aids purification of the blood, by altering potentially harmful chemicals into harmless ones, and then: either secretes them with the bile for elimination in the stool, or back into the blood, where they then are removed by the kidneys and eliminated in the urine. The typical non-specific symptoms of degenerative liver disease (loss of appetite, nausea/vomiting, lethargy, etc.) are common first “symptoms” of “adverse reaction” to Bravecto®.
The dog’s pancreas (endocrine and digestive system) produces insulin hormones (regulates the flow of glucose/sugar) and enzymes that break down fat and proteins to aid in the digestion of foods. When overburdened, the pancreas becomes inflamed, and the flow of enzymes into the digestive tract is disrupted; the enzymes may be forced out of the pancreas and into the abdominal area. These digestive enzymes will begin to break down fat and proteins in other organs… (the body begins to digest itself). Because of their proximity, the kidneys and liver are prime targets of this progression.
Enterohepatic Circulation that leads to hepatic toxicity/
And as a side note would it be under investigation by the EMA as well as Sweden, Germany, Netherlands if there were not serious concerns?
