[USA]

Hi aimee

You wrote:

“Experimentally compounds that mimic the hormone CCK result in pancreatitis. In these studies high amounts are given.”

From the book you referenced: “Applied Veterinary Clinical Nutrition 2012”. Caps added by me:

“EXPERIMENTAL PANCREATITIS can be initiated by HYPERSTIMULATION with CCK ANALOGS (Morita et al. 1998; Saluja et al. 2007), BUT THE IMPORTANCE OF THESE MECHANISMS IN SPONTANEOUS DISEASE IS UNKNOWN.”

The book says they used CCK ANALOGS, NOT CCK and that HYPERSTIMULATION was induced. This is different than the CCK released during a high protein and/or high fat meal eaten by a dog! And the book also says “THE IMPORTANCE OF THESE MECHANISMS IN SPONTANEOUS DISEASE IS UNKNOWN.” So the book admits that they don’t know the importance of their findings for dogs who get pancreatitis in the real world and not from hyperstimulation of the pancreas with CCK analogs in the lab!

You also wrote:

“The most potent dietary stimulation of CCK is fat. Protein though also stimulates CCK release.”

What the book actually says is: (caps added by me)

In dogs, fatty acids (Sun et al. 1992), amino acids, and peptides stimulate CCK release, BUT INTACT PROTEINS DO NOT (Meyer and Kelly 1976).

What are the intact proteins the book references? Are they the proteins in a raw or lightly cooked fresh homemade diet of lean meats, poultry and fish?